Researchers at Texas A&M University have developed a promising technique to rejuvenate ageing human cells by enhancing
their energy production systems. The study focusses on mitochondria - tiny structures within cells that generate
energy-which tend to decline in number and efficiency as we age. This deterioration is linked to various age-related
diseases, including those affecting the heart and brain.
To counter this, scientists used specially designed "nanoflowers," which are microscopic particles shaped like flowers.
These particles help reduce harmful oxygen molecules in cells and activate genes that stimulate the production of new
mitochondria in human stem cells.
Importantly, these energized stem cells can transfer healthy mitochondria to nearby damaged cells, restoring their
function. While it's more like a "battery replacement" than a recharge, this breakthrough could lead to innovative
treatments for degenerative diseases and age-related health issues.
"We have trained healthy cells to share their spare batteries with weaker ones," says biomedical engineer Akhilesh
"By increasing the number of mitochondria inside donor cells, we can help aging or damaged cells regain their vitality -
without any genetic modification or drugs."
Scientists developed nanoflowers from molybdenum disulfide, designed with microscopic pores that act like sponges to
absorb harmful reactive oxygen species in targeted tissues. This process triggered gene activity that boosted
mitochondria production in stem cells during lab tests.
Stem cells naturally share mitochondria, but with increased numbers, they transfer nearly twice as many to neighbouring
cells. This significantly enhanced energy restoration, especially in smooth muscle cells, which grew three to four times
In heart cells damaged by chemotherapy, the treated group showed a much higher survival rate.
Researchers believe this technique could potentially rejuvenate cells in various parts of the body-such as near the
heart for cardiovascular treatment or directly into muscles for conditions like muscular dystrophy.