A fresh investigation has revealed a potential connection between exposure to so-called “forever chemicals” and the
development of multiple sclerosis, a debilitating, lifelong illness. These persistent synthetic compounds, found in a
wide array of everyday products ranging from non-stick cookware to waterproof clothing and even dental floss, have been
under increasing scrutiny for their potential health impacts.
The new research, published in *Environment International*, indicates that individuals with significant exposure to two
major environmental toxins—perfluorooctane sulfonic acid (PFOS) and polychlorinated biphenyls (PCBs)—demonstrate a
higher likelihood of receiving a diagnosis of multiple sclerosis (MS).
Kim Kultima, who spearheaded the Sweden-based study, stated in a press release that several individual substances,
including PFOS and hydroxylated PCBs (byproducts of PCB breakdown within the body), correlated with increased odds of an
MS diagnosis. Kultima further noted that individuals exhibiting the highest concentrations of PFOS and PCBs faced
approximately twice the risk of an MS diagnosis compared to those with the lowest concentrations.
Multiple sclerosis, according to the Mayo Clinic, is a chronic autoimmune condition characterized by the breakdown of
the protective sheath surrounding nerve fibers. This degradation disrupts communication between the brain and body,
leading to symptoms such as numbness, weakness, impaired mobility, vision disturbances, and can eventually result in
Involving 900 newly diagnosed MS patients, researchers compared blood samples from these individuals with those of a
control group without MS. The team, led by Kultima, assessed toxin levels within each group's blood samples. Using
statistical modeling, the scientists examined the correlation between chemical exposure and the likelihood of developing
MS. Since people are frequently exposed to mixtures of chemicals concurrently, the study also investigated the effects
of exposure to multiple toxins.
Aina Vaivade, the study's lead author, explained that increases in total chemical exposure were linked to higher odds of
MS, even after accounting for established lifestyle and genetic risk factors.
Furthermore, the study explored the interplay between genetics, chemical exposure, and MS risk. Researchers discovered
that individuals carrying a particular gene variant typically associated with reduced MS risk exhibited unexpectedly
increased odds of diagnosis when exposed to higher levels of PFOS. Kultima suggested that these findings point to a
complex interaction between genetic predisposition and environmental factors in the development of MS.
Previous research has linked “forever chemicals,” known for their persistence in the body, to a range of health problems
including cancer, fetal complications, liver and kidney ailments, thyroid issues, fertility problems, and autoimmune
The authors of this recent study emphasize the need for further research into the effects of combined exposure to
multiple “forever chemicals.” Vaivade noted the importance of considering chemical mixtures, rather than individual
substances, when assessing the impact of PFAS and other chemicals on human health, as people are commonly exposed to
several substances simultaneously.
Even though the EPA banned PCBs in the U.S. back in 1979, these chemicals persist in the environment. Meanwhile, PFAS
continue to be utilized in numerous products, from fast food packaging to smartwatch straps. Kultima believes
understanding the interactions between environmental contaminants and hereditary factors is crucial, as it could yield
valuable insights into the origins of MS and potentially other diseases.